Abstract: 2.25Cr-1Mo-0.25V steel, as the core material for high-temperature and high-pressure hydrogen service equipment such as hydrogenation reactors, has garnered significant research attention regarding its weldability, elevated-temperature mechanical behavior, and hydrogen embrittlement susceptibility. This paper reviews recent domestic and international research advancements in microstructural regulation of welded joints, optimization of high-temperature mechanical properties, and hydrogen embrittlement mitigation strategies for 2.25Cr-1Mo-0.25V steel. Studies have revealed that two aspects have emerged as research priorities: the influence mechanisms of welding process parameters coupled with heat treatment schedules on carbide evolution and high-temperature mechanical properties in 2.25Cr-1Mo-0.25V steel, as well as the correlation between hydrogen trap distribution characteristics and hydrogen embrittlement susceptibility in this material. Future research directions include elucidating material property degradation mechanisms under multi-field coupled service environments and establishing lifetime performance prediction models through microstructural regulation strategies.